|
KMID : 1234920210210020049
|
|
Journal of Korean Oriental Association for Study of Obesity
2021 Volume.21 No. 2 p.49 ~ p.58
|
|
|
Effects of White Pan Bread Added with Kamut (Triticum turgidum spp.) on High Fat Diet-Induced Obese C57BL/6 Mice
|
|
Jung Hyun-Gi
Baek Ji-Yun
Choi Ye-Jung
Kang Ki-Sung
Kim Hyun-Young
Kim Ji-Hyun
Choi Jine-Shang
|
|
|
Abstract
|
|
|
Objectives: The purpose of this study was to investigate the effect of white pan bread added with Kamut (Triticum turgidum spp.) on high fat diet (HFD)-induced obese C57BL/6 mice.
Methods: The white pan bread or white pan bread with Kamut (BK) were administered for 8 weeks in HFD-induced obese C57BL/6 mice. To evaluate the effect and its mechanisms of BK on obese mice, we measured body weight change, serum lipid profiles, histopathological analysis, and protein expression of CCAAT/enhancer binding protein-α (C/EBPα) in the liver.
Results: Administration of BK significantly decreased body weight in HFD-induced obese mice. In addition, BK-administered group significantly reduced serum total cholesterol, glucose, and high-density lipoprotein cholesterol levels compared with the HFD-induced control group. The HFD-induced mice had damaged liver tissue and increased the size of adipose tissue, but BK-administered group attenuated liver damage and decreased the size of adipocyte. Furthermore, administration of BK significantly down-regulated C/EBPα in the liver compared with HFD-fed mice. In particular, BK-administered group has higher inhibited body weight, serum lipid profiles, and C/EBPα expressions than white pan bread-administered group.
Conclusions: This study demonstrated that administration of BK attenuated HFD-induced obesity by regulation of C/EBPα than consumption of white pan bread. Therefore, BK could be developed as a bread for prevention of obesity.
|
|
|
KEYWORD
|
|
|
High-fat diet, Obesity, Triticum, Kamut, White pan bread
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|